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THE ROLE OF POTASSIUM CHANNELS IN THE PATHOGENESIS OF GASTROINTESTINAL CANCERS AND THERAPEUTIC POTENTIAL

2020-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Voltage sensitive potassium channels play an important role in controlling membrane potential and ionic homeostasis in the gut and have been implicated in gastrointestinal (GI) cancers. Through large scale analysis of 1594 patients with GI cancers coupled with in vitro models we find KCNQ family genes are mutated in ~30% of patients, and play therapeutically targetable roles in GI cancer growth...

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Literature Corpus work
d19ddc47-8cb3-5796-b13a-868bc9fdf8ac
DOI
10.1101/2020.03.10.984039
Open publication

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