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Article

Adaptive Evolution Favoring KLK4 Downregulation in East Asians.

Molecular biology and evolution - 1 Jan 2016

Marques Patrícia Isabel, Fonseca Filipa, Sousa Tânia, Santos Paulo, Camilo Vânia, Ferreira Zélia, Quesada Victor, Seixas Susana

Abstract excerpt

The human kallikrein (KLK) cluster, located at chromosome 19q13.3-13.4, encodes 15 serine proteases, including neighboring genes (KLK3, KLK2, KLK4, and KLK5) with key roles in the cascades of semen liquefaction, tooth enamel maturation, and skin desquamation. KLK2 and KLK3 were previously identified as targets of adaptive evolution in primates through different mechanisms linked to reproductive biology and, in...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26420451
DOI: 10.1093/molbev/msv199

Genes

KLK4
KLK3
KLK2
KLK5
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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