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Article

CYP2A6 genotype but not age determines cotinine half-life in infants and children.

Clinical pharmacology and therapeutics - 1 Sept 2013

Dempsey D A, Sambol N C, Jacob P, Hoffmann E, Tyndale R F, Fuentes-Afflick E, Benowitz N L

Abstract excerpt

The formation of cotinine, the main proximate metabolite and a biomarker of nicotine exposure, is mediated primarily by cytochrome P450 (CYP)2A6. Our aim was to determine whether higher cotinine levels in young children exposed to secondhand smoke (SHS) are a result of age-related differences in...

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Identifiers

PMID: 23714690
DOI: 10.1038/clpt.2013.114
PMCID: PMC3820275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23714690-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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