Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes.

British journal of haematology - 1 Aug 2013

Alter Blanche P, Rosenberg Philip S, Day Thomas, Menzel Stephan, Giri Neelam, Savage Sharon A, Thein Swee Lay

Abstract excerpt

Patients with inherited bone marrow failure syndromes (IBMFS) have 'stress erythropoiesis', with anaemia, macrocytosis, increased fetal haemoglobin (Hb F) and high erythropoietin levels. In haemoglobinopathies, Hb F levels are regulated by 3 quantitative trait loci, HBS1L-MYB, BCL11A and Xmn1-HBG2. In our study of 97 patients with an IBMFS, increased Hb F was associated with young age, male gender, anaemia, high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Diamond-Blackfan
Share to Bone Marrow Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Failure Disorders

Share to Dyskeratosis Congenita

Share to Exocrine Pancreatic Insufficiency

Share to gamma-Globins

Share to Genes, myb

Share to Lipomatosis

Source

Open in PubMed Open full text

Identifiers

PMID: 23713742
DOI: 10.1111/bjh.12399
PMCID: PMC3720816

Genes

HBG2
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes.PMID 23713742Read ↗

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in XMN1-HBG2, HBS1L-MYB, and BCL11A and Their Relation to High Fetal Hemoglobin Levels That Alleviate AnemiaSemantic proximity Read ↗

Genetic architecture of hemoglobin F controlSemantic proximity Read ↗

Discovering the genetics underlying foetal haemoglobin production in adultsSemantic proximity Read ↗

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania.Semantic proximity Read ↗

Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approachesSemantic proximity Read ↗

Three fingers on the switchSemantic proximity Read ↗

Polymorphic variations influencing fetal hemoglobin levels: association study in beta-thalassemia carriers and in normal individuals of Portuguese origin.Semantic proximity Read ↗

Influences of genetic variation on fetal hemoglobin.Semantic proximity Read ↗

Modifier genes in Mendelian disorders: the example of hemoglobin disorders.Semantic proximity Read ↗

Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania.Semantic proximity Read ↗

Genetic control of erythropoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.