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Article

Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system

28 May 2013

Abstract excerpt

Chemoresistance is one of the most critical prognostic factors in osteosarcoma, and elucidation of the molecular backgrounds of chemoresistance may lead to better clinical outcomes. Spheroid cells resemble in vivo cells and are considered an in vitro model for the drug discovery. We found that spheroid cells displayed more chemoresistance than conventional monolayer cells across 11 osteosarcoma cell lines. To...

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PMID: 23712969
DOI: 10.1002/pmic.201300053

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