Article

Three-dimensional multicellular spheroid-induced 5-fluorouracil drug resistance provokes global alterations of HeLa carcinoma cells: a multi-omics analysis

2024-01-31

Abstract excerpt

Cervical cancer is a serious health problem in women around the globe, with 600 thousand new cases each year. However, the use of clinical drug is seriously dampened by the development of drug resistance, which has been evidenced to be associated with metabolic reprogramming and heterogeneity in tumor cells. Efficient in vitro tumor model is essential to improve the efficiency of drug screening and the accuracy of...

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Literature Corpus work: 2cf0403f-c6ac-509e-90bc-c348225516bd
DOI: 10.22541/au.170666530.05240464/v1

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