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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

27 Oct 2018

Abstract excerpt

Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar...

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PMID: 30367820
DOI: 10.1002/bit.26845

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