Article
Pathologic patterns of interleukin 10 expression--a review.
Biochemia medica - 1 Jan 2015
Trifunović Jasenka, Miller Larisa, Debeljak Željko, Horvat Vesna
Abstract excerpt
Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription start site and three single nucleotide polymorphisms (SNPs) -1082(G/A), -819(C/T) and -592(C/A). A...
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