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Article

Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees.

Journal of virology - 1 Aug 1990

Nara P L, Smit L, Dunlop N, Hatch W, Merges M, Waters D, Kelliher J, Gallo R C, Fischinger P J, Goudsmit J

Abstract excerpt

Emergence in two chimpanzees of human immunodeficiency virus type 1 (HIV-1) IIIB variants resistant to neutralization by the preexisting antibody is described. Viruses isolated from the HIV-1 IIIB gp120-vaccinated and -challenged animal were more resistant to neutralization by the chimpanzee's own serum than viruses isolated from the naive infected animal, indicating immune pressure as the selective mechanism....

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Source

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Identifiers

PMID: 2370681
DOI: 10.1128/JVI.64.8.3779-3791.1990
PMCID: PMC249673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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