Article
Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees.
Journal of virology - 1 Aug 1990
Nara P L, Smit L, Dunlop N, Hatch W, Merges M, Waters D, Kelliher J, Gallo R C, Fischinger P J, Goudsmit J
Abstract excerpt
Emergence in two chimpanzees of human immunodeficiency virus type 1 (HIV-1) IIIB variants resistant to neutralization by the preexisting antibody is described. Viruses isolated from the HIV-1 IIIB gp120-vaccinated and -challenged animal were more resistant to neutralization by the chimpanzee's ow...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Genetic Variation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Molecular Sequence Data
- Neutralization Tests
- Oligonucleotide Probes