Article
Evidence for rapid selection and deletion of HIV-1 subpopulations in vivo by V3-specific neutralizing antibody: a model of humoral-associated selection.
Developments in biological standardization - 1 Jan 1990
Nara P, Smit L, Dunlop N, Hatch W, Merges M, Waters D, Kelliher J, Krone W, Goudsmit J
Abstract excerpt
Emergence in two chimpanzees of HIV-1 HTLV-IIIB variants resistant to neutralization by the pre-existing antibody is described. Viruses isolated from the HTLV-IIIB gp120 vaccinated and challenged animal were more resistant to neutralization, had more heterogenic genomes and showed more pronounced...
Topics
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Base Sequence
- Cell Line
- Cells, Cultured
- Cloning, Molecular
- Genotype
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Neutralization Tests