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Article

Differences in dynamic structure of LC8 monomer, dimer, and dimer-peptide complexes.

Biochemistry - 18 Nov 2008

Hall Justin, Hall Andrea, Pursifull Nathan, Barbar Elisar

Abstract excerpt

Dimerization of dynein light chain LC8 creates two symmetric grooves at the dimer interface with diverse binding capabilities. In addition to pH and protein concentration, dimerization is affected by phosphorylation, as illustrated by a phosphomimetic mutation that promotes dissociation of LC8 to a monomer and subsequent dissociation from the dynein complex in vitro. In this work we characterize the dynamic...

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Identifiers

PMID: 18942858
DOI: 10.1021/bi801093k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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