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Article

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

26 May 2013

Abstract excerpt

BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation at specific gene loci to activate lineage-restricted elements. However, the exact mechanisms facilitating the erasure...

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PMID: 23705593
DOI: 10.1186/gb-2013-14-5-r46

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