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Article

Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.

European journal of neurology - 1 Oct 2013

Malhotra S, Morcillo-Suárez C, Nurtdinov R, Rio J, Sarro E, Moreno M, Castilló J, Navarro A, Montalban X, Comabella M

Abstract excerpt

BACKGROUND AND PURPOSE: Ubiquitin specific peptidase 18 (USP18) is a deubiquitinating enzyme that functions as a negative regulator of the type I interferon (IFN) signalling pathway and is specifically induced by type I IFNs. In the present study, previous observations by our group were expanded suggesting an implication of USP18 in multiple sclerosis (MS) based on the finding of a deficient expression of the...

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Source

Identifiers

PMID: 23700969
DOI: 10.1111/ene.12193

Genes

USP18
ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.PMID 23700969Read ↗

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