Article
Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.
PloS one - 18 Feb 2010
Mishto Michele, Bellavista Elena, Ligorio Claudia, Textoris-Taube Kathrin, Santoro Aurelia, Giordano Mara, D'Alfonso Sandra, Listì Florinda, Nacmias Benedetta, Cellini Elena, Leone Maurizio, Grimaldi Luigi M E, Fenoglio Chiara, Esposito Federica, Martinelli-Boneschi Filippo, Galimberti Daniela, Scarpini Elio, Seifert Ulrike, Amato Maria Pia, Caruso Calogero, Foschini Maria P, Kloetzel Peter M, Franceschi Claudio
Abstract excerpt
BACKGROUND: Albeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and...
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