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Article

A scan for human-specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes.

Molecular biology and evolution - 1 Aug 2013

Somel Mehmet, Wilson Sayres Melissa A, Jordan Gregory, Huerta-Sanchez Emilia, Fumagalli Matteo, Ferrer-Admetlla Anna, Nielsen Rasmus

Abstract excerpt

Environmental or genomic changes during evolution can relax negative selection pressure on specific loci, permitting high frequency polymorphisms at previously conserved sites. Here, we jointly analyze population genomic and comparative genomic data to search for functional processes showing rela...

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Share to Evolution, Molecular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Share to Proteasome Endopeptidase Complex

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Identifiers

PMID: 23699470
DOI: 10.1093/molbev/mst098
PMCID: PMC3708504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23699470-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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