Article
Cloning of ACP33 as a novel intracellular ligand of CD4.
The Journal of biological chemistry - 23 Mar 2001
Zeitlmann L, Sirim P, Kremmer E, Kolanus W
Abstract excerpt
CD4 recruitment to T cell receptor (TCR)-peptide-major histocompatibility class II complexes is required for stabilization of low affinity antigen recognition by T lymphocytes. The cytoplasmic portion of CD4 is thought to amplify TCR-initiated signal transduction via its association with the protein tyrosine kinase p56(lck). Here we describe a novel functional determinant in the cytosolic tail of CD4 that...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- CD4 Antigens
- COS Cells
- Carrier Proteins
- Cell Line
- Cloning, Molecular
- Endosomes
- Golgi Apparatus
- Humans
- Ligands
- Lymphocyte Activation
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Binding