Article
Cloning of ACP33 as a novel intracellular ligand of CD4.
The Journal of biological chemistry - 23 Mar 2001
Zeitlmann L, Sirim P, Kremmer E, Kolanus W
Abstract excerpt
CD4 recruitment to T cell receptor (TCR)-peptide-major histocompatibility class II complexes is required for stabilization of low affinity antigen recognition by T lymphocytes. The cytoplasmic portion of CD4 is thought to amplify TCR-initiated signal transduction via its association with the protein tyrosine kinase p56(lck). Here we describe a novel functional determinant in the cytosolic tail of CD4 that...
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