Article
A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.
PloS one - 1 Jan 2013
Mechelli Rosella, Umeton Renato, Policano Claudia, Annibali Viviana, Coarelli Giulia, Ricigliano Vito A G, Vittori Danila, Fornasiero Arianna, Buscarinu Maria Chiara, Romano Silvia, Salvetti Marco, Ristori Giovanni
Abstract excerpt
Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a "candidate interactome" (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease...
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