Article

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis

2019-05-01

Abstract excerpt

<h4>SUMMARY</h4> We exploited genetic information to assess the role of non-genetic factors in multifactorial diseases. To this aim we isolated candidate “interactomes” (i.e. groups of genes whose products are known to physically interact with environmental exposures and biological processes, plausibly relevant for disease pathogenesis) and analyzed nominal statistical evidence of association with genetic predisp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d27ac00e-9e45-55f4-a224-aa047752a62e
DOI: 10.1101/624049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosisDOI 10.1101/624049Read

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus associationSemantic proximity Read

A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.Semantic proximity Read

Exploring the role of EBV in multiple sclerosis pathogenesis through EBV interactomeSemantic proximity Read

A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosisSemantic proximity Read

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis.Semantic proximity Read

VirTrack: A Framework for Inferring Viral Influence on Disease-Associated Transcriptomes — Clinical Type-Specific Epstein–Barr Virus Pathogenesis in Multiple SclerosisSemantic proximity Read

Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibilitySemantic proximity Read

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunitiesSemantic proximity Read

The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.Semantic proximity Read

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders.Semantic proximity Read

Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis.Semantic proximity Read

Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple SclerosisSemantic proximity Read