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Article

Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.

PLoS pathogens - 1 Jan 2013

Kitamura Kouichi, Wang Zhe, Chowdhury Sajeda, Simadu Miyuki, Koura Miki, Muramatsu Masamichi

Abstract excerpt

The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC) DNA (partially double-stranded DNA) into cccDNA in the nucleus. Recently, antiviral cytidine deaminases, AID/APOBEC proteins, were shown to generate uracil residues in the NC-DNA through deamination, resulting in...

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Identifiers

PMID: 23696735
DOI: 10.1371/journal.ppat.1003361
PMCID: PMC3656096

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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