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Article

TGF-β triggers HBV cccDNA degradation through AID-dependent deamination.

FEBS letters - 1 Feb 2016

Qiao Ying, Han Xiaoxu, Guan Gefei, Wu Na, Sun Jianbo, Pak Vladimir, Liang Guoxin

Abstract excerpt

The covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is a viral center molecule for HBV infection and persistence. However, the cellular restriction factors of HBV cccDNA are not well understood. Here, we show that TGF-β can induce nuclear viral cccDNA degradation and hypermutation via activation-induced cytidine deaminase (AID) deamination activity in hepatocytes. This suppression by TGF-β is...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26867650
DOI: 10.1002/1873-3468.12058

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UNG

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