Article
Rheumatoid arthritis in Israeli Jews: shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility.
The Journal of rheumatology - 1 Jun 1991
Gao X, Gazit E, Livneh A, Stastny P
Abstract excerpt
Rheumatoid arthritis (RA) is known to be associated with class II HLA antigens in most populations, but recent studies in Israeli Jewish patients showed no significant differences in either DR4 or DR1 between patients and controls. In a previous DR4 subset study we found DR4-Dw15 to be associated...
Topics
- Alanine
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- Glycine
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans
- Immunoglobulin Variable Region
- Israel
- Jews
- Molecular Sequence Data
- Oligonucleotides
- Polymerase Chain Reaction
- Risk Factors
- Valine