Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression.

doi:10.1371/journal.pone.0063699

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Article

Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression.

PloS one - 1 Jan 2013

Gallego Xavier, Cox Ryan J, Laughlin James R, Stitzel Jerry A, Ehringer Marissa A

Abstract excerpt

Common genetic factors strongly contribute to both nicotine, the main addictive component of tobacco, and alcohol use. Several lines of evidence suggest nicotinic acetylcholine receptors as common sites of action for nicotine and alcohol. Specifically, rs1948, a single-nucleotide polymorphism (SNP) located in the CHRNB4 3'-untranslated region (UTR), has been associated to early age of initiation for both alcohol...

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PMID: 23691088
DOI: 10.1371/journal.pone.0063699
PMCID: PMC3653846

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CHRNB4

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