Article
Differential expression of the inflammasome complex genes in systemic lupus erythematosus.
Immunogenetics - 1 May 2020
da Cruz Heidi Lacerda Alves, Cavalcanti Catarina Addobbati Jordão, de Azêvedo Silva Jaqueline, de Lima Camilla Albertina Dantas, Fragoso Thiago Sotero, Barbosa Alexandre Domingues, Dantas Andréa Tavares, de Ataíde Mariz Henrique, Duarte Angela Luzia Branco Pinto, Pontillo Alessandra, Crovella Sergio, Sandrin-Garcia Paula
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving heterogeneous clinical manifestations and numerous susceptibility genes. Several findings evidence the critical role of inflammasomes in the predisposition to autoimmune diseases and in SLE. We investigated whether inflammasome polymorphins could affect susceptibility to develop and/or severity SLE. Moreover, differences in inflammasome...
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