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Article

The central role of angiotensin I-converting enzyme in vertebrate pathophysiology.

Current topics in medicinal chemistry - 1 Jan 2004

Moskowitz David W, Johnson Frank E

Abstract excerpt

Genomic epidemiologic data, increasingly supported by clinical outcomes results, strongly suggest that overactivity of angiotensin I-converting enzyme (ACE) may underlie most age-related diseases. Angiotensin II, the main product of ACE, is a pleiotropic hormone, capable of serving as a neurotransmitter, growth factor, angiogenesis factor, vasoconstrictor, pro-thrombotic agent, and cytokine. So it is perhaps not...

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Source

Identifiers

PMID: 15379656
DOI: 10.2174/1568026043387818

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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