Article
Sequence kernel association test for survival traits.
Genetic epidemiology - 1 Apr 2014
Chen Han, Lumley Thomas, Brody Jennifer, Heard-Costa Nancy L, Fox Caroline S, Cupples L Adrienne, Dupuis Josée
Abstract excerpt
Rare variant tests have been of great interest in testing genetic associations with diseases and disease-related quantitative traits in recent years. Among these tests, the sequence kernel association test (SKAT) is an omnibus test for effects of rare genetic variants, in a linear or logistic regression framework. It is often described as a variance component test treating the genotypic effects as random. When...
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