Article
Direct evidence of a functional separation of alloreactive T lymphocytes from bystander cells infiltrating rat allografts. Interleukin 2 receptor-positive cells reacting with the monoclonal antibody ART 18 mediating second-set rejection.
Transplantation - 1 Jul 1990
Heidecke C D, Brauer R, Schneider-Eicke J, Schilling T, Wolff S, Diamantstein T
Abstract excerpt
In this study we examined the functional capacity of unseparated, IL-2R positive and IL-2R negative leukocytes infiltrating BN rat hearts or kidneys grafted into allogeneic LEW rats. Upon adoptive transfer into syngeneic LEW recipients, splenocytes or day-3 graft infiltrate cells of either cardia...
Topics
- Animals
- Antibodies, Monoclonal
- CD4 Antigens
- Graft Rejection
- Heart Transplantation
- Immunization, Passive
- Kidney Transplantation
- Male
- Phenotype
- Rats
- Rats, Inbred Strains