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Article

Host-based Th2 cell therapy for prolongation of cardiac allograft viability.

PloS one - 29 Apr 2011

Amarnath Shoba, Chen Hao, Foley Jason E, Costanzo Carliann M, Sennesh Joel D, Solomon Michael A, Fowler Daniel H

Abstract excerpt

Donor T cell transfusion, which is a long-standing approach to prevent allograft rejection, operates indirectly by alteration of host T cell immunity. We therefore hypothesized that adoptive transfer of immune regulatory host Th2 cells would represent a novel intervention to enhance cardiac allograft survival. Using a well-described rat cardiac transplant model, we first developed a method for ex vivo manufacture...

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Identifiers

PMID: 21559526
DOI: 10.1371/journal.pone.0018885
PMCID: PMC3084712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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