Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Renal allograft rejection in CD4+ T cell-reconstituted athymic nude rats. The origin of CD4+ and CD8+ graft-infiltrating cells.

Transplantation - 1 Dec 1990

Gracie J A, Sarawar S R, Bolton E M, Bradley J A, Tanaka T, Bell E B

Abstract excerpt

PVG-rnu/rnu nude rats reject a fully allogeneic DA renal allograft after the adoptive transfer of naive CD4+ T cells alone, but rejection is accompanied by the accumulation of many CD8+ leukocytes within the graft. In order to clearly establish the provenance of these CD8+ cells infiltrating rejecting kidney allografts, nude recipients (PVG-RT7a) were injected with CD4+ T cells from the PVG-RT7b congenic strain...

Topics

Animals
CD4-Positive T-Lymphocytes
Graft Rejection
Kidney Transplantation
Phenotype
Rats
Rats, Inbred Strains
Rats, Nude
Receptors, Antigen, T-Cell
T-Lymphocytes, Regulatory
Transplantation, Homologous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1979453
DOI: 10.1097/00007890-199012000-00020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979453-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal allograft rejection in CD4+ T cell-reconstituted athymic nude rats. The origin of CD4+ and CD8+ graft-infiltrating cells.PMID 1979453Read ↗

Allograft rejection in athymic nude rats by transferred T cell subsets. II. The response of naive CD4+ and CD8+ thoracic duct lymphocytes to an isolated MHC class I disparity.Semantic proximity Read ↗

Replacement of graft-resident donor-type antigen presenting cells alters the tempo and pathogenesis of murine cardiac allograft rejection.Semantic proximity Read ↗

Xenotransplantation: immunological hurdles and progress toward toleranceSemantic proximity Read ↗

Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells.Semantic proximity Read ↗

Cytotoxic T-cell elimination during anti-CD4-induced rat liver acceptance and rapid replacement of functional graft antigen-presenting cells.Semantic proximity Read ↗

Predominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO.Semantic proximity Read ↗

Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft RejectionSemantic proximity Read ↗

Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.Semantic proximity Read ↗

Survival and function of CD47-deficient thymic grafts in mice.Semantic proximity Read ↗

Role of regulated upon activation normal T-cell expressed and secreted in a model of retransplantation acute rejection mediated by alloreactive memory CD4+ T cells.Semantic proximity Read ↗

The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.Semantic proximity Read ↗

Comparison of activation requirements and activation phenotype of allogeneic and xenogeneic rodent responses in vivo and in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.