Tagging SNPs in the ERCC4 gene are associated with gastric cancer risk.

doi:10.1016/j.gene.2013.03.046

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Article

Tagging SNPs in the ERCC4 gene are associated with gastric cancer risk.

Gene - 25 May 2013

Chu Haiyan, Zhao Qinghong, Wang Shizhi, Wang Meilin, Xu Ming, Gao Yan, Luo Dewei, Tan Yongfei, Gong Weida, Zhang Zhengdong, Wu Dongmei

Abstract excerpt

ERCC4 plays an essential role in the nucleotide excision repair (NER) pathway, which is involved in the removal of a wide variety of DNA lesions. To determine whether the ERCC4 tagging SNPs (tSNPs) are associated with risk of gastric cancer, we conducted a hospital-based case-control study of 350 cases and 468 cancer-free controls. In the logistic regression (LR) analysis, we found a significantly decreased risk...

Topics

Aged
Asian People
Case-Control Studies
DNA-Binding Proteins
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Haplotypes
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 23537993
DOI: 10.1016/j.gene.2013.03.046

Genes

ERCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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