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Article

X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.

Journal of medicinal chemistry - 13 Jun 2013

Molodtsov Vadim, Nawarathne Irosha N, Scharf Nathan T, Kirchhoff Paul D, Showalter H D Hollis, Garcia George A, Murakami Katsuhiko S

Abstract excerpt

Rifampin, a semisynthetic rifamycin, is the cornerstone of current tuberculosis treatment. Among many semisynthetic rifamycins, benzoxazinorifamycins have great potential for TB treatment due to their superior affinity for wild-type and rifampin-resistant Mycobacterium tuberculosis RNA polymerases and their reduced hepatic Cyp450 induction activity. In this study, we have determined the crystal structures of the...

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Share to Antibiotics, Antitubercular
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Escherichia coli Proteins

Share to Holoenzymes

Share to Protein Conformation

Share to Transcription, Genetic

Source

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Identifiers

PMID: 23679862
DOI: 10.1021/jm4004889
PMCID: PMC3745299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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