Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.

Science (New York, N.Y.) - 4 Dec 2009

Edwards Marcus J, Flatman Ruth H, Mitchenall Lesley A, Stevenson Clare E M, Le Tung B K, Clarke Thomas A, McKay Adam R, Fiedler Hans-Peter, Buttner Mark J, Lawson David M, Maxwell Anthony

Abstract excerpt

Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and simocyclinone D8, revealing two binding pockets t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coumarins
Share to Crystallography, X-Ray
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosides

Share to Ligands

Share to Molecular Weight

Share to Protein Multimerization

Share to Topoisomerase II Inhibitors

Source

Identifiers

PMID: 19965760
DOI: 10.1126/science.1179123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19965760-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.PMID 19965760Read ↗

In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.Semantic proximity Read ↗

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticusSemantic proximity Read ↗

Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding ModeSemantic proximity Read ↗

Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteriaSemantic proximity Read ↗

NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor.Semantic proximity Read ↗

Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.Semantic proximity Read ↗

A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA GyraseSemantic proximity Read ↗

Biological activities of novel gyrase inhibitors of the aminocoumarin class.Semantic proximity Read ↗

Structure of a DNA glycosylase that unhooks interstrand cross-links.Semantic proximity Read ↗

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyaseSemantic proximity Read ↗

Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage Φ29 DNA mimic protein p56.Semantic proximity Read ↗

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by DiazabicyclooctanesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.