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Article

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase.

The EMBO journal - 14 Jul 2015

Szymanski Michal R, Kuznetsov Vladmir B, Shumate Christie, Meng Qingchao, Lee Young-Sam, Patel Gayatri, Patel Smita, Yin Y Whitney

Abstract excerpt

The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex bound to either substrate or zalcitabine, an inhibitor used for HIV reverse transcriptase. The structures reveal that zalcitabine...

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Share to Catalytic Domain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

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Source

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Identifiers

PMID: 26056153
DOI: 10.15252/embj.201591520
PMCID: PMC4547898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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