Article
[Significance of the acetylator phenotype and initial oral/intravenous rifampicin administration in the treatment of tuberculosis].
Pneumologie (Stuttgart, Germany) - 1 Feb 1990
Loos U, Musch E, Schwabe H K
Abstract excerpt
In a pilot study involving 62 patients with open pulmonary tuberculosis, we established that slow acetyators and patients receiving intravenous rifampicin treatment showed a tendency towards a more rapid negativisation of the sputum culture than did fast acetyators (lower levels of isoniazid) or patients receiving oral rifampicin therapy (decreasing bioavailability of the rifampicin during treatment).
Topics
- Acetylation
- Administration, Oral
- Ethambutol
- Humans
- Isoniazid
- Metabolic Clearance Rate
- Mixed Function Oxygenases
- Phenotype
- Rifampin
- Tuberculosis, Pulmonary