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Article

Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype.

Hepatology (Baltimore, Md.) - 1 Jan 2000

Yamamoto T, Suou T, Hirayama C

Abstract excerpt

Of 143 patients with pulmonary tuberculosis receiving isoniazid therapy, 52 (36%) had a transient elevation in serum aminotransferases. Among 74 patients taking isoniazid, rifampicin and streptomycin, 35 (47%) had such an increase, while of 69 patients taking isoniazid, amino-salicylic acid and streptomycin, 17 (24%) did; this difference was significant. Isoniazid therapy could be continued in all patients with...

Topics

Acetylation
Adult
Aged
Antitubercular Agents
Chromatography, High Pressure Liquid
Drug Therapy, Combination
Female
Humans
Isoniazid
Kinetics
Liver
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Transaminases

Tuberculosis, Pulmonary

Source

Identifiers

PMID: 3957235
DOI: 10.1002/hep.1840060223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3957235-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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