Article
[Antitubercular agents: pharmacogenetic factors in the development of adverse effects].
Revista medica de Chile - 1 Jul 1990
Ligueros M, Saavedra H, Neira S, Cruz-Coke R, Saavedra A, Kramer V, Gelman M, Nuñez A, Prieto J C
Abstract excerpt
We studied the distribution of the acetylator phenotype in 47 patients aged 15 to 77 years receiving isonyazid as antituberculous therapy. 62% were fast and 32% slow acetylators. Ethnical, socio-economic and biologic factors were not related to acetylator type. The incidence of liver alterations, mainly elevated transaminase levels, was higher than reported in the literature and was not shown to be influenced by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.