[Antitubercular agents: pharmacogenetic factors in the development of adverse effects].

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Article

[Antitubercular agents: pharmacogenetic factors in the development of adverse effects].

Revista medica de Chile - 1 Jul 1990

Ligueros M, Saavedra H, Neira S, Cruz-Coke R, Saavedra A, Kramer V, Gelman M, Nuñez A, Prieto J C

Abstract excerpt

We studied the distribution of the acetylator phenotype in 47 patients aged 15 to 77 years receiving isonyazid as antituberculous therapy. 62% were fast and 32% slow acetylators. Ethnical, socio-economic and biologic factors were not related to acetylator type. The incidence of liver alterations,...

Topics

Acetylation
Acetyltransferases
Adolescent
Adult
Aged
Alkaline Phosphatase
Antitubercular Agents
Aspartate Aminotransferases
Chile
Female
Humans
Isoniazid
Liver
Male
Middle Aged
Phenotype
Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 2131519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2131519-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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