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Article

The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.

Molecular and cellular biology - 1 Jan 2006

Leeds Nina B, Small Eliza C, Hiley Shawna L, Hughes Timothy R, Staley Jonathan P

Abstract excerpt

Biogenesis of the small and large ribosomal subunits requires modification, processing, and folding of pre-rRNA to yield mature rRNA. Here, we report that efficient biogenesis of both small- and large-subunit rRNAs requires the DEAH box ATPase Prp43p, a pre-mRNA splicing factor. By steady-state analysis, a cold-sensitive prp43 mutant accumulates 35S pre-rRNA and depletes 20S, 27S, and 7S pre-rRNAs, precursors to...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16382143
DOI: 10.1128/MCB.26.2.513-522.2006
PMCID: PMC1346897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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