Article
Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.
Scientific reports - 16 Sept 2016
Blondel Marc, Soubigou Flavie, Evrard Justine, Nguyen Phu Hai, Hasin Naushaba, Chédin Stéphane, Gillet Reynald, Contesse Marie-Astrid, Friocourt Gaëlle, Stahl Guillaume, Jones Gary W, Voisset Cécile
Abstract excerpt
6AP and GA are potent inhibitors of yeast and mammalian prions and also specific inhibitors of PFAR, the protein-folding activity borne by domain V of the large rRNA of the large subunit of the ribosome. We therefore explored the link between PFAR and yeast prion [PSI(+)] using both PFAR-enriched mutants and site-directed methylation. We demonstrate that PFAR is involved in propagation and de novo formation of...
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