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Article

Identification of Alzheimer disease-associated variants in genes that regulate retromer function.

Neurobiology of aging - 1 Sept 2012

Vardarajan Badri N, Bruesegem Sophia Y, Harbour Michael E, Inzelberg Rivka, Friedland Robert, St George-Hyslop Peter, Seaman Matthew N J, Farrer Lindsay A

Abstract excerpt

The proteolytic processing of amyloid precursor protein (APP) to generate the neurotoxic amyloid β (Aβ) peptide is central to the pathogenesis of Alzheimer disease (AD). The endocytic system mediates the processing of APP by controlling its access to secretases that cleave APP. A key mediator of...

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Identifiers

PMID: 22673115
DOI: 10.1016/j.neurobiolaging.2012.04.020
PMCID: PMC3391348

Genes

APP
SNX3
SNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22673115-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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