Article
The Rb1 gene inhibits the viability of retinoblastoma cells by regulating homologous recombination.
International journal of molecular medicine - 1 Jul 2013
Yang Ying, Tian Sijia, Brown Bryce, Chen Pei, Hu Huan, Xia Lei, Zhang Jing, Cai Xiaoxiao, Chen Zhao, Pan Xueke, Ge Jian, Yu Keming, Zhuang Jing
Abstract excerpt
Retinoblastoma is a childhood ocular tumor caused by the inactivation of both alleles of the retinoblastoma gene (Rb1). Without Rb1 gene function, chromosomal aberrations are observed in retinoblastoma cells. The instability of the genome is closely associated with the repair of DNA double-strand breaks (DSBs). However, the precise molecular mechanism of action of Rb1 in DNA DSB repair remains unclear. Thus, in...
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