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RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapy

18 Jun 2015

Abstract excerpt

Inactivation of the retinoblastoma (RB1) tumor suppressor is one of the most frequent and early recognized molecular hallmarks of cancer. RB1, although mainly studied for its role in the regulation of cell cycle, emerged as a key regulator of many biological processes. Among these, RB1 has been implicated in the regulation of apoptosis, the alteration of which underlies both cancer development and resistance to...

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PMID: 26160835
DOI: 10.18632/oncotarget.4286

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