Monoclonal origin of concordant T-cell malignancy in identical twins.

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Article

Monoclonal origin of concordant T-cell malignancy in identical twins.

Blood - 1 Jan 1997

Ford A M, Pombo-de-Oliveira M S, McCarthy K P, MacLean J M, Carrico K C, Vincent R F, Greaves M

Abstract excerpt

Acute leukemia has a high concordance rate in young identical twins and in infants this is known, from molecular analysis, to reflect an in utero origin in one twin followed by prenatal metastasis to the other twin via intraplacental anastomoses. The situation in older twins with leukemia has bee...

Topics

Alleles
Base Sequence
Cell Lineage
Child
Clone Cells
Diseases in Twins
Female
Fetofetal Transfusion
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin Heavy Chains

Leukemia-Lymphoma, Adult T-Cell

Lymphoma, T-Cell

Male

Molecular Sequence Data

Neoplasm Proteins

Source

Open in PubMed

Identifiers

PMID: 8978302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8978302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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