Article
Monoclonal origin of concordant T-cell malignancy in identical twins.
Blood - 1 Jan 1997
Ford A M, Pombo-de-Oliveira M S, McCarthy K P, MacLean J M, Carrico K C, Vincent R F, Greaves M
Abstract excerpt
Acute leukemia has a high concordance rate in young identical twins and in infants this is known, from molecular analysis, to reflect an in utero origin in one twin followed by prenatal metastasis to the other twin via intraplacental anastomoses. The situation in older twins with leukemia has been less clear. We describe a pair of identical twins who were diagnosed with a T-cell malignancy at 9 and 11 years of...
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