Phenotypic and Molecular Features of Somatically Derived "Yolk Sac Tumors": Similarities and Differences With Counterparts of Germ Cell Origin.

doi:10.1016/j.modpat.2025.100807

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Article

Phenotypic and Molecular Features of Somatically Derived "Yolk Sac Tumors": Similarities and Differences With Counterparts of Germ Cell Origin.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2025

Lobo João, Tavares Nuno Tiago, Fernandes-Pontes Fernanda, Fonseca Diana, Jerónimo Carmen, Henrique Rui, Ricci Costantino, de Leo Antonio, Collins Katrina, Idrees Muhammad T, Ulbright Thomas M, Gupta Sounak, Acosta Andres M

Abstract excerpt

A subset of somatic carcinomas shows morphologic and immunophenotypic similarities to yolk sac tumor (YST) of germ cell origin, including fetal adenocarcinomas of the lung and somatic carcinomas with "YST"/enteroblastic differentiation. At least some of these tumors may result from reprogramming somatic cancer cells, leading to the acquisition of a "pluripotent" phenotype. Although these somatic tumors express...

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Topics

Humans
MicroRNAs
Endodermal Sinus Tumor
Phenotype
Neoplasms, Germ Cell and Embryonal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Biomarkers, Tumor

In Situ Hybridization, Fluorescence

Immunohistochemistry

Adult

Middle Aged

Adolescent

Source

Open in PubMed

Identifiers

PMID: 40484319
DOI: 10.1016/j.modpat.2025.100807

Genes

FOXA2
SALL4

Provenance

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