Article
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.
Nature genetics - 1 Aug 2015
Mohankumar Kumarasamypet M, Currle David S, White Elsie, Boulos Nidal, Dapper Jason, Eden Christopher, Nimmervoll Birgit, Thiruvenkatam Radhika, Connelly Michele, Kranenburg Tanya A, Neale Geoffrey, Olsen Scott, Wang Yong-Dong, Finkelstein David, Wright Karen, Gupta Kirti, Ellison David W, Thomas Arzu Onar, Gilbertson Richard J
Abstract excerpt
Cancers are characterized by non-random chromosome copy number alterations that presumably contain oncogenes and tumor-suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here we report a cross-species in vivo screen of 84 candidate oncogenes and 39 candidate TSGs, located within 28 recurrent chromosomal alterations in ependymoma. Through...
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