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Article

Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

PloS one - 1 Jan 2013

Richardson Tom G, Thomas Elaine C, Sessions Richard B, Lawlor Debbie A, Tavaré Jeremy M, Day Ian N M

Abstract excerpt

Obesity is now a leading cause of preventable death in the industrialised world. Understanding its genetic influences can enhance insight into molecular pathogenesis and potential therapeutic targets. A non-synonymous polymorphism (rs35859249, p.Arg125Trp) in the N-terminal TBC1D1 phosphotyrosine-binding (PTB) domain has shown a replicated association with familial obesity in women. We investigated these findings...

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Identifiers

PMID: 23667688
DOI: 10.1371/journal.pone.0063897
PMCID: PMC3646766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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