R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

doi:10.1093/hmg/ddn070

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R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

Human molecular genetics - 15 Jun 2008

Meyre David, Farge Morgane, Lecoeur Cécile, Proenca Christine, Durand Emmanuelle, Allegaert Frédéric, Tichet Jean, Marre Michel, Balkau Beverley, Weill Jacques, Delplanque Jérôme, Froguel Philippe

Abstract excerpt

Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result in 9714 French Caucasian individuals, combining family-based and general population studies. We confirmed an association with familial obesity (defined as body mass index (BMI) > or = 97th percentile) in women from 1109...

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PMID: 18325908
DOI: 10.1093/hmg/ddn070

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