More than half of annotated human miRNAs are never expressed at levels sufficient for biological function

Abstract excerpt

MicroRNAs (miRNAs) are widely studied for their role in post-transcriptional gene regulation, often using exogenous overexpression systems to reveal their functions. However, such approaches may not accurately reflect endogenous miRNA activity due to the substantially higher expression levels achieved experimentally. To address this, we sought to determine the minimal endogenous expression threshold required for a...

Topics

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• Base Pairing
• Drug Development
• Drug Evaluation, Preclinical
• Gene Silencing
• MicroRNAs
• RNA Interference
• Structure-Activity Relationship
• Treatment Outcome

Identifiers and source

Literature Corpus work

7bb24dc9-55ad-5cef-911d-834b1e0b8dd5

DOI

10.1101/2024.12.05.626958