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Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα<sub>12/13</sub>-Rho-Rac1 pathway

10 May 2013

Abstract excerpt

BACKGROUND: Ovarian cancer G protein coupled receptor 1 (OGR1) mediates inhibitory effects on cell migration in human prostate and ovarian cancer cells. However, the mechanisms and signaling pathways that mediate these inhibitory effects are essentially unknown. METHODS: MCF7 cell line was chosen as a model system to study the mechanisms by which OGR1 regulates cell migration, since it expresses very low levels...

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PMID: 23663350
DOI: 10.1186/1750-2187-8-6

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