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Article

A Synthetic Biology Approach Reveals a CXCR4-G <sub>13</sub> -Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells

20 Sept 2011

Abstract excerpt

Tumor cells can co-opt the promigratory activity of chemokines and their cognate G protein-coupled receptors (GPCRs) to metastasize to regional lymph nodes or distant organs. Indeed, the migration toward SDF-1 (stromal cell-derived factor 1) of tumor cells bearing CXCR4 [chemokine (C-X-C motif) receptor 4] has been implicated in the lymphatic and organ-specific metastasis of various human malignancies. Here, we...

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PMID: 21934106
DOI: 10.1126/scisignal.2002221

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