Article
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231.
BMC cancer - 23 Nov 2012
Aguilar-Rojas Arturo, Huerta-Reyes Maira, Maya-Núñez Guadalupe, Arechavaleta-Velásco Fabián, Conn P Michael, Ulloa-Aguirre Alfredo, Valdés Jesús
Abstract excerpt
BACKGROUND: Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Nevertheless, the signaling pathways whereby the activated GnRH/GnRHR system exerts this effect have not been clearly established. In this study, we provide experimental evidence that describes...
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