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Article

Constitutively active androgen receptor variants upregulate expression of mesenchymal markers in prostate cancer cells.

PloS one - 1 Jan 2013

Cottard Félicie, Asmane Irène, Erdmann Eva, Bergerat Jean-Pierre, Kurtz Jean-Emmanuel, Céraline Jocelyn

Abstract excerpt

Androgen receptor (AR) signaling pathway remains the foremost target of novel therapeutics for castration-resistant prostate cancer (CRPC). However, the expression of constitutively active AR variants lacking the carboxy-terminal region in CRPC may lead to therapy inefficacy. These AR variants are supposed to support PCa cell growth in an androgen-depleted environment, but their mode of action still remains...

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Identifiers

PMID: 23658830
DOI: 10.1371/journal.pone.0063466
PMCID: PMC3642121

Genes

ZEB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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